Studying the Effects of an Investigational Bone Matrix Fiber on Bone Healing in Dogs Undergoing TTA for CCL Insufficiency

The University of Florida College of Veterinary Medicine is currently recruiting dogs with cranial cruciate ligament insufficiency that are candidates for the TTA repair technique.

  • Inclusion Criteria:  Any Dog with cranial cruciate ligament insufficiency between the ages of 2-8 years and weighing between 30-45kg.
  • Treatment: Dogs participating in this study will undergo a tibial tuberosity advancement surgery as treatment for their cranial cruciate ligament (CCL) insufficiency. This is a standard procedure for the treatment of CCL insufficiency and its efficacy has been documented in numerous, large clinical studies. This procedure is being used as it produces a standardized bony defect in which bone graft can be placed. Your dog will be randomly allocated to receive 1 of 2 graft preparations (A or B). Bone healing of this defect will be assessed by computed tomography (CT) and radiographs (x-rays).  Your dog will undergo the following additional procedures at the time of initial treatment and at 4, 8, and 12 weeks after initial treatment.       1) Complete examination, including orthopedic examination
    2) CT imaging and radiographs of both stifles
    At the end of 12 weeks after surgery, your dog’s participation in this study will be complete.
  • Costs: The study will cover the cost of the orthopedic implants required for the surgery (worth approximately $500), the CT imaging, recheck radiographs and associated sedation charges, 2 of the 3 recheck examination charges and all gait analysis charges. You will be charged for the costs of the orthopedic implants and the force-plate analysis if follow-up visits are not completed, and your dog has not been removed from the study.
  • Contact:  You can contact our Small Animal Hospital by calling 352-392-2235 Dr. Stanley Kim is the Primary Investigator and Dr. Sarah Townsend is the Resident and Project Coordinator.


Bone healing is a vital component of many orthopedic surgeries in both human and veterinary medicine. In some cases, bone healing can be delayed or non-existent. To encourage appropriate bone healing, a number of techniques have been developed. Grafting is a commonly used technique involving the collection of tissue from one part of the body and its deposition into another part. Bone grafts can be harvested from a patient’s own bone (autogenous bone graft);  however, its collection requires an additional surgical approach to be performed, increasing surgical time and patient morbidity. Allogenic bone graft, a graft collected from animals of the same species, has been developed to alleviate these concerns and limitations.

The purpose of this study is to evaluate the effect of an investigational allogenic form of bone graft, a demineralized bone matrix fiber preparation on bone healing in dogs and compare it to a commercially available bone graft.