Characterization of the Cellular and Cytokine Constituents of Bone Marrow Concentrate in Dogs with Musculoskeletal Injury of Disease

The University of Florida College of Veterinary Medicine is currently recruiting dogs with musculoskeletal injury or disease for a clinical research trial.

  • Inclusion Criteria:  Healthy dogs greater than 25 kilograms (55 lbs) with conditions causing arthritis, delayed fracture healing, and tendon injuries.
  • Procecures/Treatment: Bone marrow will be collected with a needle from both front legs (humeral bones) under sedation. The bone marrow aspirate will then be concentrated patient-side and a portion of the bone marrow concentrate will be injected into the clinically affected joint or lesion. The remainder of the sample will be retained for characterization in the laboratory.
  • Costs: The study will cover all costs related to the bone marrow concentrate procedure (collection of bone marrow, preparation and injection of concentrate). This study will not cover costs of medications (including sedation), ultrasound (if needed), or any other procedures
  • Contact:  If you would like to be considered for the study, please call the UF Small Animal Hospital to schedule an appointment for your dog with the Surgery Service at (352) 392-2235. For other questions regarding the study, please email us at: VM-ClinicalStudies@ufl.edu

 

Background:

Bone marrow concentrate (BMC) is a product made by concentrating bone marrow aspirate collected from a patient. The process is rapid and can be performed in the operating room or under brief heavy sedation. The resultant concentrate contains stem cells and other cells and factors that have individually been shown to improve healing. BMC is a substance that is currently being used with increasing frequency in veterinary and human medicine to promote or enhance healing or growth of various tissues. The content of BMC is well-studied in people; however, its characteristics are largely unknown in dogs. The goal of this study is to characterize BMC compared with unconcentrated bone marrow in dogs and provide fundamental knowledge to the veterinary community.