The University of Florida Small Animal Hospital offers Clinical Trials for dogs, cats, and other small animals to determine efficacy and safety for future treatments, therapies, and diagnostic tools.

Please complete our Study Inquiry form to see if we have a clinical trial that may suit your pet’s needs.

Current Clinical Trials in Dogs:

Internal Medicine

• Energy Needs of ‘Giant’ Breed Dogs while Resting and Exercising on a Treadmill (Currently Enrolling)
• Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs (Currently Enrolling)
• Potential Reduction of Systemic and Pancreatic Inflammation Using Fenofibrate in Diabetic Dogs (Currently Enrolling)

Neurology

• Autogenic Vaccine Study in Dogs with Glioma (Brain Tumor) (Currently Enrolling)
• Use of Hemp Based Nutraceuticals as an Adjunctive Agent in Dogs with Epilepsy (Enrollment CLOSED)

Cancer

• Acellular Fish Skin as a Free Xenograft for Immediate Wound Coverage Following Wide Surgical Tumor Excision in Dogs (Currently Enrolling)
• Evaluation of Imaging and Intraoperative Techniques for the Identification of Sentinel Lymph Nodes in Dogs with Oral Tumors (Currently Enrolling)
• Evaluation of Real-Time Near-Infrared Fluorescence (NIRF) Quantification to Detect Malignant Lesions in the Canine Liver via Laparotomy or Laparoscopy (Currently Enrolling)
• Vaccine Study for Dogs with Melanoma (Currently Enrolling)
• Vaccine Study for Dogs with Appendicular Osteosarcoma (Currently Enrolling)
• Evaluation of Outcomes for Dogs Receiving L-Asparaginase and Prednisone Dual Therapy for Palliative Treatment of High Grade Lymphoma (On Hold)
• A Pilot Study to Determine the Safety and Efficacy of CBD Oil Use During Chemotherapy in Dogs with Lymphoma (Enrollment CLOSED)
• Melanocortin 4 Receptor Antagonist in the Treatment of Canine Cachexia (Enrollment CLOSED)

Dermatology

• Intradermal Immunotherapy with a Heat-Killed Actinomycetales Bacterin Preparation as Adjunctive Treatment for Canine Oomycoses: A Multicentric, Randomized, Controlled, Clinical Trial (Currently Enrolling)
• Investigational Vaccine for Dogs with Atopic Dermatitis (Currently Enrolling)

Cardiology

• Collection of Domesticated Animal Hearts for a Tissue Bank (Currently Enrolling)
• Gene Therapy for Dilated Cardiomyopathy in Dobermans (Currently Enrolling)
• Evaluating the effect of taurine supplementation on the renin-angiotensin-aldosterone system (RAAS) in dogs (Currently Enrolling)
• Tolerability and Clinical Efficacy of Acetazolamide for Treatment of Hypochloremia in Canine Congestive Heart Failure (Currently Enrolling)

Surgery

• A Comparison of Soft Palate Length and Thickness in English and French bulldogs Following a Staphylectomy or Folded-flap Palatoplasty (Currently Enrolling)
• Description of Laparoscopic Ultrasound of the Liver in Healthy Dogs (Currently Enrolling)
• Investigation of Ioban Use During Canine Celiotomy to Determine Potential Benefits of Thermoregulation, Patient Dryness, and Reduction of Surgical Site Complications (Currently Enrolling)
• Description of a Novel Approach for Thoracic Duct Ligation and Embolization in Dogs with Idiopathic Chylothorax (Enrollment on HOLD)
• Evaluation of the Efficacy and Safety of a Novel Short Stem Total Hip Replacement in Dogs with Hip Osteoarthritis Secondary to Hip Dysplasia (Enrollment on HOLD)
• Prospective Randomized Cross-Over Clinical Trial Comparing Two Different Post-Operative (Spay Surgery) Devices for Incisional Protection and Client Satisfaction (Enrollment on HOLD)
• Characterization of the Cellular and Cytokine Constituents of Bone Marrow Concentrate in Dogs with Musculoskeletal Injury or Disease (Enrollment CLOSED)

Anesthesia and Pain Management

• Erector Spinae Plane Block in Dogs Undergoing Spinal Surgery (Currently Enrolling)

Integrative Medicine

• Evaluation of the Effect of Mitragynine on Naturally Occurring Osteoarthritic Pain in a Canine Model, a Prospective, Randomized, Crossover, Double-Blinded, Placebo-Controlled Clinical Trial (Currently Enrolling)
• Surface Electromyography of the Vastus Lateralis and Gluteus Medius Muscles in Post-Operative T3-L3 Hemilaminectomy Dogs (Currently Enrolling)

Current Clinical Trials in Cats:

Internal Medicine

• Collection of Thyroid tissue from Cats (Currently Enrolling)
• Correlation of Ammonia Excretion with Renal Function in Cats with Chronic Kidney Disease (Currently Enrolling)
• Exenatide Extended-Release for extending remission time in diabetic cats (Currently Enrolling)

Dermatology

• Investigational Vaccine for Cats with Feline Hypersensitivity Dermatitis (Currently Enrolling)

Forensic Pathology

• The Minimally Invasive Veterinary Autopsy: A Feasibility Study (Currently Enrolling)

Cardiology

• Fibroblast Cell Isolation and Expansion and iPSC Derivation in Purebred Maine Coon and Ragdoll Cats (Enrollment CLOSED)

Cancer

• Feline RNA Nanoparticle Vaccine against Oral Squamous Cell Carcinoma (Currently Enrolling)