Gut Microbiome in Canine Diabetes

The University of Florida College of Veterinary Medicine is currently recruiting dogs with diabetes and healthy control dogs for a clinical research study. The study will evaluate the bacteria in the gut of dogs with and without diabetes.

  • Inclusion Criteria: Dogs with a diagnosis of diabetes or healthy adult dog (control group)
  • Exclusion criteria: Dogs that have received oral or injectable antibiotics within the past 3 months or dogs with major concurrent disease, especially intestinal disease.
  • Procedures: A stool sample will be collected either after voluntary defecation, or by rectal exam.
  • Costs: The study will cover the cost of collection of the stool and the microbial analysis of the stool. All other costs are the responsibility of the client.
  • Contact:
  • PI: Allison O’Kell, DVM, MS, DACVIM   (352) 294-4471  aokell@ufl.edu
  • Study Coordinator: Lana Fagman, MS, (352) 294-4389, VM-ClinicalStudies@ufl.edu

 

Background:

Studies in humans have identified a possible role for the bacteria (also known as microbiome) in the gut to have a role in the development of type 1 diabetes. Given these findings, it is possible that changing the gut bacteria could lead to new therapies to treat or prevent diabetes. Diabetes in dogs has some similarities to type 1 diabetes in humans, but the nature of the gut microbiome in dogs with diabetes has not yet been studied.  The objective of this preliminary study is to compare the gut microbiome in dogs with diabetes to healthy non-diabetic dogs. Results of this study may identify differences in the gut microbiome between diabetic and healthy dogs. If differences are present, there may be potential to develop new therapies for canine diabetes related to the gut microbiome.