Rowan J Milner,
Professor & Director, SACS
Department:
Small Animal Clinical Sciences
Business Phone:
(352) 392-2235
Business Email:
milnerr@ufl.edu
Accomplishments
Award for Veterinary Research Excellence
2011
·
Pfizer
Faculty Enhancement Opportunity Award
2009
·
Office of the Provost, UF
Clinical Researcher of the Year Award
2007
·
Florida Kennel Club
Clinician of the Year Award, Class of 2007
2007
·
University of Florida
Clinician of the Year Award, Class of 2004
2004
·
University of Florida
Presidents Choice Award, Abstract & Poster
2004
·
55th Annual Meeting of the American Association for the Study of Liver Diseases
Teaching Profile
Courses Taught
2006,2015-2025
VME6905 Problems in Veterinary Medical Sciences
2006-2007,2009-2025
VEM5308 Vet Med Oncology
2020-2025
VEM5872C Veterinary Medical & Radiation Oncology Clerkship
2010,2013-2015,2015-2025
VEM5110 Animal Systems 1
2010,2015-2018,2018-2025
VEM5131 Vet Molecular Biology
2015-2022
VEM5171 Vet Pharmacology
2006-2020
VEM5873 Oncology Clrkshp Elec
2014-2015,2017-2025
GMS6065 Fundamentals of Cancer Biology
2018
VME7980 Research for Doctoral Dissertation
2012-2013,2024-2025
VEM5286 Vet Clin Pharmacology
2006-2007
VEM5201L Lge Anim Phys Diag
2025
VME7979 Advanced Research
Board Certifications
-
Diplomate (Internal Medicine)European College of Veterinary Internal Medicine
-
Diplomate (Oncology)American College of Veterinary Internal Medicine
-
Diplomate (Oncology)European College of Veterinary Internal Medicine
Research Profile
Research Interests
– Osteosarcoma
– Melanoma vaccine
– Stereotactic radiosurgery
– Targeted radiotherapy
– Tumor suppressor genes
Publications
Academic Articles
2024
RNA aggregates harness the danger response for potent cancer immunotherapy.
Cell.
187(10):2521-2535.e21
[DOI] 10.1016/j.cell.2024.04.003.
[PMID] 38697107.
2023
Characterization of expression and prognostic implications of GD2 and GD3 synthase in canine histiocytic sarcoma.
Veterinary immunology and immunopathology.
259
[DOI] 10.1016/j.vetimm.2023.110594.
[PMID] 37058951.
2023
Characterization of expression and prognostic implications of transforming growth factor beta, programmed death-ligand 1, and T regulatory cells in canine histiocytic sarcoma.
Veterinary immunology and immunopathology.
257
[DOI] 10.1016/j.vetimm.2023.110560.
[PMID] 36804838.
2023
mRNA aggregates harness danger response for potent cancer immunotherapy.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.03.12.23287108.
[PMID] 36993772.
2023
Safety of TCMCB07, a melanocortin-4 antagonist peptide, in dogs with naturally occurring cachexia.
Journal of veterinary internal medicine.
37(6):2344-2355
[DOI] 10.1111/jvim.16915.
[PMID] 37897303.
2022
Identification of the interleukin-8 (CXCL-8) pathway in feline oral squamous cell carcinoma – A pilot study.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
86(1):13-19
[PMID] 34975217.
2022
RNA in situ hybridisation as a molecular diagnostic technique targeting IBA-1 and CD204 in canine histiocytic sarcoma.
Veterinary medicine and science.
8(4):1400-1408
[DOI] 10.1002/vms3.795.
[PMID] 35339118.
2021
Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing.
Veterinary immunology and immunopathology.
231
[DOI] 10.1016/j.vetimm.2020.110144.
[PMID] 33278779.
2021
Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.
Veterinary immunology and immunopathology.
232
[DOI] 10.1016/j.vetimm.2020.110169.
[PMID] 33387703.
2021
Novel application of single-cell next-generation sequencing for determination of intratumoral heterogeneity of canine osteosarcoma cell lines
Journal of Veterinary Diagnostic Investigation.
33(2):261-278
[DOI] 10.1177/1040638720985242.
[PMID] 33446089.
2020
GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas.
American journal of cancer research.
10(2):674-687
[PMID] 32195035.
2019
Characterization of myeloid-derived suppressor cells and cytokines GM-CSF, IL-10 and MCP-1 in dogs with malignant melanoma receiving a GD3-based immunotherapy.
Veterinary immunology and immunopathology.
216
[DOI] 10.1016/j.vetimm.2019.109912.
[PMID] 31446208.
2018
Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
28(2):130-139
[DOI] 10.1111/vec.12695.
[PMID] 29469204.
2018
Response rate to a single dose of vinblastine administered to dogs with treatment-naive multicentric lymphoma.
Veterinary and comparative oncology.
16(4):636-641
[DOI] 10.1111/vco.12433.
[PMID] 30117260.
2017
Clinical Response and Adverse Event Profile of Bleomycin Chemotherapy for Canine Multicentric Lymphoma.
Journal of the American Animal Hospital Association.
53(2):128-134
[DOI] 10.5326/JAAHA-MS-6598.
[PMID] 27841682.
2017
Retrospective Evaluation of Whole Body Computed Tomography for Tumor Staging in Dogs with Primary Appendicular Osteosarcoma.
Veterinary surgery : VS.
46(1):75-80
[DOI] 10.1111/vsu.12579.
[PMID] 27906470.
2016
ASSOCIATION BETWEEN COMPUTED TOMOGRAPHIC CHARACTERISTICS AND FRACTURES FOLLOWING STEREOTACTIC RADIOSURGERY IN DOGS WITH APPENDICULAR OSTEOSARCOMA.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
57(3):321-30
[DOI] 10.1111/vru.12351.
[PMID] 26916056.
2016
In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines.
Veterinary and comparative oncology.
14(3):281-94
[DOI] 10.1111/vco.12100.
[PMID] 24976212.
2016
Outcome After Pneumonectomy in 17 Dogs and 10 Cats: A Veterinary Society of Surgical Oncology Case Series.
Veterinary surgery : VS.
45(6):782-9
[DOI] 10.1111/vsu.12517.
[PMID] 27399196.
2016
Outcome of definitive fractionated radiation followed by exenteration of the nasal cavity in dogs with sinonasal neoplasia: 16 cases.
Veterinary and comparative oncology.
14(4):350-360
[DOI] 10.1111/vco.12115.
[PMID] 25178539.
2016
OUTCOMES AND PROGNOSTIC FACTORS ASSOCIATED WITH CANINE SINONASAL TUMORS TREATED WITH CURATIVE INTENT CONE-BASED STEREOTACTIC RADIOSURGERY (1999-2013).
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
57(3):331-40
[DOI] 10.1111/vru.12349.
[PMID] 26880676.
2015
Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs.
Veterinary and comparative oncology.
13(4):409-23
[DOI] 10.1111/vco.12056.
[PMID] 24007303.
2014
Effects of aurothiomalate treatment on canine osteosarcoma in a murine xenograft model.
Anti-cancer drugs.
25(3):332-9
[DOI] 10.1097/CAD.0000000000000061.
[PMID] 24304691.
2014
Stereotactic radiosurgery and fracture fixation in 6 dogs with appendicular osteosarcoma.
Veterinary surgery : VS.
43(2):174-81
[DOI] 10.1111/j.1532-950X.2014.12082.x.
[PMID] 24393054.
2014
Synthesis of polymeric phosphonates for selective delivery of radionuclides to osteosarcoma.
Cancer biotherapy & radiopharmaceuticals.
29(7):273-82
[DOI] 10.1089/cbr.2014.1615.
[PMID] 25111903.
2013
Apoptotic effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine osteosarcoma cells.
Anti-cancer drugs.
24(5):519-26
[DOI] 10.1097/CAD.0b013e32836002ba.
[PMID] 23466652.
2013
Effect of bevacizumab on angiogenesis and growth of canine osteosarcoma cells xenografted in athymic mice.
American journal of veterinary research.
74(5):771-8
[DOI] 10.2460/ajvr.74.5.771.
[PMID] 23627391.
2013
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia.
Anti-cancer drugs.
24(10):1098-103
[DOI] 10.1097/CAD.0000000000000018.
[PMID] 23995854.
2012
In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines.
Veterinary and comparative oncology.
10(3):223-35
[DOI] 10.1111/j.1476-5829.2012.00335.x.
[PMID] 22594682.
2012
Use of samarium Sm 153 lexidronam for the treatment of dogs with primary tumors of the skull: 20 cases (1986-2006).
Journal of the American Veterinary Medical Association.
240(11):1310-5
[DOI] 10.2460/javma.240.11.1310.
[PMID] 22607597.
2011
Acute hyperammonemia after L-asparaginase administration in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
21(6):673-8
[DOI] 10.1111/j.1476-4431.2011.00695.x.
[PMID] 22316261.
2011
BCR-ABL translocation in a dog with chronic monocytic leukemia.
Veterinary clinical pathology.
40(1):40-7
[DOI] 10.1111/j.1939-165X.2010.00277.x.
[PMID] 21143615.
2011
Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009).
Journal of the American Veterinary Medical Association.
239(2):209-15
[DOI] 10.2460/javma.239.2.209.
[PMID] 21756176.
2011
MRI measurement of bone marrow cellularity for radiation dosimetry.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
52(9):1482-9
[DOI] 10.2967/jnumed.111.087957.
[PMID] 21799087.
2011
Oronasal fistula repair utilizing a temporalis muscle flap in a dog with severe trismus.
Journal of the American Animal Hospital Association.
47(6):447-54
[DOI] 10.5326/JAAHA-MS-5699.
[PMID] 22058353.
2011
Radical excision with five-centimeter margins for treatment of feline injection-site sarcomas: 91 cases (1998-2002).
Journal of the American Veterinary Medical Association.
239(1):97-106
[DOI] 10.2460/javma.239.1.97.
[PMID] 21718202.
2011
Radiosensitivity and capacity for radiation-induced sublethal damage repair of canine transitional cell carcinoma (TCC) cell lines.
Veterinary and comparative oncology.
9(3):232-40
[DOI] 10.1111/j.1476-5829.2010.00258.x.
[PMID] 21848626.
2010
Migration and differentiation of canine bone marrow stromal cells transplanted into the developing mouse brain.
The Journal of veterinary medical science.
72(3):353-6
[PMID] 19952514.
2010
Radiosenstivity and Capacity for Radiation-Induced Sublethal Damage Repair of Canine Transitional Cell Carcinoma Cell Lines
Journal of Veterinary Internal Medicine.
24
2009
Development of an intramuscular xenograft model of canine osteosarcoma in mice for evaluation of the effects of radiation therapy.
American journal of veterinary research.
70(1):127-33
[DOI] 10.2460/ajvr.70.1.127.
[PMID] 19119958.
2009
Radiation therapy for canine appendicular osteosarcoma.
Veterinary and comparative oncology.
7(1):15-27
[DOI] 10.1111/j.1476-5829.2008.00177.x.
[PMID] 19222827.
2008
Canine anatomic phantom for preclinical dosimetry in internal emitter therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
49(3):446-52
[DOI] 10.2967/jnumed.107.046722.
[PMID] 18287264.
2008
Cisplatin: a review of toxicities and therapeutic applications.
Veterinary and comparative oncology.
6(1):1-18
[DOI] 10.1111/j.1476-5829.2007.00142.x.
[PMID] 19178659.
2008
Hyperbilirubinemia’s protective effect against cisplatin nephrotoxicity in the Gunn rat.
Anti-cancer drugs.
19(5):495-502
[DOI] 10.1097/CAD.0b013e3282fdc391.
[PMID] 18418216.
2008
Immunophenotypic and cytomorphologic subclassification of T-cell lymphoma in the boxer breed.
Veterinary immunology and immunopathology.
125(1-2):102-10
[DOI] 10.1016/j.vetimm.2008.05.009.
[PMID] 18579219.
2008
Intrinsic radiosensitivity and repair of sublethal radiation-induced damage in canine osteosarcoma cell lines.
American journal of veterinary research.
69(9):1197-202
[DOI] 10.2460/ajvr.69.9.1197.
[PMID] 18764694.
2006
Comparison of canine cardiac troponin I concentrations as determined by 3 analyzers.
Journal of veterinary internal medicine.
20(5):1136-42
[PMID] 17063706.
2006
Efficacy and toxicity of BOPP and LOPP chemotherapy for the treatment of relapsed canine lymphoma.
Veterinary and comparative oncology.
4(1):21-32
[DOI] 10.1111/j.1476-5810.2006.00088.x.
[PMID] 19754826.
2006
Survival times for cats with hyperthyroidism treated with iodine 131, methimazole, or both: 167 cases (1996-2003).
Journal of the American Veterinary Medical Association.
228(4):559-63
[PMID] 16478432.
2006
The immune response to disialoganglioside GD3 vaccination in normal dogs: a melanoma surface antigen vaccine.
Veterinary immunology and immunopathology.
114(3-4):273-84
[PMID] 17027091.
2005
Cardiac troponin I concentrations in normal dogs and cats using a bedside analyzer.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
7(1):27-32
[DOI] 10.1016/j.jvc.2005.02.001.
[PMID] 19083315.
2005
Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs.
American journal of veterinary research.
66(5):885-91
[PMID] 15934617.
2005
Investigation of the effects of deracoxib and piroxicam on the in vitro viability of osteosarcoma cells from dogs.
American journal of veterinary research.
66(11):1961-7
[PMID] 16334957.
2005
Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003).
Journal of the American Veterinary Medical Association.
227(7):1118-22
[PMID] 16220673.
2004
Bisphosphonates and cancer.
Journal of veterinary internal medicine.
18(5):597-604
[PMID] 15515572.
2004
Stereotactic radiosurgery for treatment of osteosarcomas involving the distal portions of the limbs in dogs.
Journal of the American Veterinary Medical Association.
225(10):1567-72, 1548
[PMID] 15568390.
2004
Suppurative rhinitis associated with Haemophilus species infection in a cat.
Journal of the South African Veterinary Association.
75(2):103-7
[PMID] 15456168.
2004
The effect of the bisphosphonate alendronate on viability of canine osteosarcoma cells in vitro.
In vitro cellular & developmental biology. Animal.
40(3-4):113-7
[PMID] 15311969.
1998
Targeted radiotherapy with Sm-153-EDTMP in nine cases of canine primary bone tumours.
Journal of the South African Veterinary Association.
69(1):12-7
[PMID] 9646255.
1997
Chronic episodic diarrhoea associated with apparent intestinal colonisation by the yeasts Saccharomyces cerevisiae and Candida famata in a German shepherd dog.
Journal of the South African Veterinary Association.
68(4):147-9
[PMID] 9561501.
1997
The effect of diminazene aceturate on cholinesterase activity in dogs with canine babesiosis.
Journal of the South African Veterinary Association.
68(4):111-3
[PMID] 9561493.
1996
Immunophenotypic classification of canine malignant lymphoma on formalin-mixed paraffin wax-embedded tissue by means of CD3 and CD79a cell markers.
The Onderstepoort journal of veterinary research.
63(4):309-13
[PMID] 9173362.
Grants
May 2024
ACTIVE
Mechanisms of immunotolerance in canine oral melanoma: an opportunity to comparative approaches
Role: Co-Project Director/Principal Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
Sep 2023
ACTIVE
Imaging, Dosimetry and Radiobiology for a-particle Emitter Radiopharmaceutical Therapy
Role: Co-Investigator
Funding: JOHNS HOPKINS UNIVERSITY
via NATL INST OF HLTH NCI
Jan 2023
– Dec 2024
Investigating the Immune Response to RNA-lipid Nanoparticle Vaccines in a Clinical Trial for Canines with Osteosarcoma
Role: Other
Funding: PEDIATRIC CANCER RESEARCH FOU
Sep 2022
ACTIVE
Overcoming metastatic spread of osteosarcoma with RNA loaded nanoparticles
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Mar 2022
ACTIVE
Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy
Role: Co-Project Director/Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIDCR
Mar 2022
ACTIVE
A GD3 nano-scaled liposomal cancer vaccine for canine hemangiosarcoma
Role: Principal Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
Feb 2021
ACTIVE
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2020
– Jun 2024
Translating Personalized RNA Nanoparticle Vaccines for Oral Cancer
Role: Co-Project Director/Principal Investigator
Funding: OCALA ROYAL DAMES FOR CANCER RESEARCH
Jul 2020
– Dec 2021
Characterization of Expression and Prognostic Implications of GD2S and GD3S in Canine Histiocytic Sarcoma
Role: Co-Investigator
Funding: VETERINARY CANCER SOCIETY
Jun 2020
– May 2023
Lipidnanoparticle vaccines targeting metastatic lung cancer from osteosarcoma
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Dec 2019
– Jun 2022
Nanoparticles targeting genetic translocations in pediatric brain tumors
Role: Co-Investigator
Funding: HYUNDAI HOPE ON WHEELS
Jul 2018
– Jun 2020
Host Immunomodulatory RNA-nanoparticles targeting malignant canine glioma
Role: Co-Investigator
Funding: UF FOUNDATION
Dec 2017
– Aug 2021
An Immunological Strategy to Osteosarcoma: Reconditioning the Immune System with Adoptive CAR-T Cells and Reversal of Regulatory Pathways.
Role: Other
Funding: HYUNDAI HOPE ON WHEELS
Jun 2017
– Apr 2019
CART Cells for Sarcoma
Role: Other
Funding: Sarcoma Foundation of America
Aug 2016
– Feb 2020
Environmental and Genetic Determinants of Transitional Cell Carcinoma of the Urinary Tract in Scottish Terriers funded by Olive's Way
Role: Faculty
Funding: UF FOUNDATION
Jan 2016
– Apr 2018
A GD2/GD3 (ganglioside) targeted cancer vaccine for canine osteosarcoma
Role: Principal Investigator
Funding: AMER KENNEL CLUB CANINE HLTH FOU
May 2015
– May 2016
A GD2/GD3 (Ganglioside) targeted cancer vaccine
Role: Principal Investigator
Funding: UF FOUNDATION
May 2014
– May 2019
Prospective, multicentre, randomised, double-blind, placebo controlled, 2-parallel groups, phase 3 study to compare efficacy and safety of masitinib to placebo in the treatment of grade 2-3 non-resectable mast cell tumors in dogs
Role: Principal Investigator
Funding: AB SCIENCE
Education
Ph.D.
2013
·
College of Medicine, University of Pretoria
Diplomate (Oncology)
2009
·
American College of Veterinary Internal Medicine
Diplomate (Oncology)
2005
·
European College of Veterinary Internal Medicine
Diplomate (Internal Medicine)
1999
·
European College of Veterinary Internal Medicine
Master of Vet Med, Medicine
1997
·
University of Pretoria
BVSc (Honors)
1993
·
University of Pretoria
BVSc
1980
·
University of Pretoria
Contact Details
Phones:
- Business:
- (352) 392-2235
Emails:
- Business:
- milnerr@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100126
GAINESVILLE FL 32610 - Business Street:
-
Veterinary Clinical Sciences
2015 S.W. 16TH AVE.
GAINESVILLE FL 32608
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