Janet Robishaw

Janet Robishaw,

ASO DEAN & PROF

Department: Department of Comparative, Diagnostic & Population Medicine
Business Phone: (352) 273-8859
Business Email: robishawj@ufl.edu

Publications

Academic Articles
2024
Post-transcriptional regulation and subcellular localization of G-protein γ7 subunit: implications for striatal function and behavioral responses to cocaine.
Frontiers in neuroanatomy. 18 [DOI] 10.3389/fnana.2024.1394659. [PMID] 38764487.
2024
Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(19) [DOI] 10.1523/JNEUROSCI.1226-23.2024. [PMID] 38569927.
2024
Reimagining the research enterprise across University of Florida’s missions.
American journal of veterinary research. 85(10) [DOI] 10.2460/ajvr.24.07.0189. [PMID] 39260404.
2023
Assessing Adherence to Multi-Modal Oura Ring Wearables From COVID-19 Detection Among Healthcare Workers.
Cureus. 15(9) [DOI] 10.7759/cureus.45362. [PMID] 37849583.
2023
Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.07.05.547546. [PMID] 37461723.
2023
Temporal trends and geographic variations in mortality rates from tobacco and firearms in the United States.
Preventive medicine. 175 [DOI] 10.1016/j.ypmed.2023.107622. [PMID] 37454875.
2022
Author Correction: Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-08723-x. [PMID] 35296773.
2022
Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-07314-0. [PMID] 35236896.
2021
Different biases in meta-analyses of case-control and cohort studies: an example from genomics and precision medicine.
Annals of epidemiology. 58:38-41 [DOI] 10.1016/j.annepidem.2021.02.013. [PMID] 33640484.
2021
Family history in first degree relatives of patients with premature cardiovascular disease.
International journal of cardiology. 333:215-218 [DOI] 10.1016/j.ijcard.2021.03.026. [PMID] 33737169.
2021
Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse.
BMC medical genomics. 14(1) [DOI] 10.1186/s12920-021-01100-z. [PMID] 34702274.
2021
Genomic surveillance to combat COVID-19: challenges and opportunities.
The Lancet. Microbe. 2(9):e481-e484 [DOI] 10.1016/S2666-5247(21)00121-X. [PMID] 34337584.
2021
Selective Manipulation of G-Protein γ7 Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(44):9065-9081 [DOI] 10.1523/JNEUROSCI.1211-21.2021. [PMID] 34544837.
2020
A simplified SARS-CoV-2 detection protocol for research laboratories.
PloS one. 15(12) [DOI] 10.1371/journal.pone.0244271. [PMID] 33338082.
2020
Assessment of Probable Opioid Use Disorder Using Electronic Health Record Documentation.
JAMA network open. 3(9) [DOI] 10.1001/jamanetworkopen.2020.15909. [PMID] 32886123.
2020
Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.
BMC medical genomics. 13(1) [DOI] 10.1186/s12920-020-00755-4. [PMID] 32711518.
2020
Establishing and Maintaining Research Integrity at Academic Institutions: Challenges and Opportunities.
The American journal of medicine. 133(3):e87-e90 [DOI] 10.1016/j.amjmed.2019.08.036. [PMID] 31520622.
2020
Multisite validation of a simple electronic health record algorithm for identifying diagnosed obstructive sleep apnea.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 16(2):175-183 [DOI] 10.5664/jcsm.8160. [PMID] 31992429.
2020
Temporal Trends and Geographic Variations in Mortality Rates from Prescription Opioids: Lessons from Florida and West Virginia.
Southern medical journal. 113(3):140-145 [DOI] 10.14423/SMJ.0000000000001074. [PMID] 32123930.
2019
Genomics and Precision Medicine to Combat Opioid Use Disorder.
The American journal of medicine. 132(4):395-396 [DOI] 10.1016/j.amjmed.2018.10.014. [PMID] 30940352.
2019
Rare-variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associations of orphan G protein-coupled receptors.
The Journal of biological chemistry. 294(48):18109-18121 [DOI] 10.1074/jbc.RA119.009253. [PMID] 31628190.
2018
Prescription of Statins to Women Poses New Clinical Challenges.
The American journal of medicine. 131(10):1139-1140 [DOI] 10.1016/j.amjmed.2018.03.034. [PMID] 29679537.
2017
TM6SF2 rs58542926 impacts lipid processing in liver and small intestine.
Hepatology (Baltimore, Md.). 65(5):1526-1542 [DOI] 10.1002/hep.29021. [PMID] 28027591.
2015
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration.
Oncogene. 34(24):3095-106 [DOI] 10.1038/onc.2014.251. [PMID] 25109332.
2014
Disruption of G-protein γ5 subtype causes embryonic lethality in mice.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0090970. [PMID] 24599258.
2012
Preferential assembly of G-αβγ complexes directed by the γ subunits.
Sub-cellular biochemistry. 63:181-91 [DOI] 10.1007/978-94-007-4765-4_10. [PMID] 23161139.
2012
Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.
The Journal of biological chemistry. 287(10):7121-33 [DOI] 10.1074/jbc.M111.308395. [PMID] 22207761.
2010
Adenosine A2A receptor signaling and golf assembly show a specific requirement for the gamma7 subtype in the striatum.
The Journal of biological chemistry. 285(39):29787-96 [DOI] 10.1074/jbc.M110.142620. [PMID] 20639202.
2009
Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.
American journal of physiology. Regulatory, integrative and comparative physiology. 297(5):R1494-502 [DOI] 10.1152/ajpregu.00308.2009. [PMID] 19759336.
2008
Myocyte-specific M-CAT and MEF-1 elements regulate G-protein gamma 3 gene (gamma3) expression in cardiac myocytes.
DNA and cell biology. 27(7):367-76 [DOI] 10.1089/dna.2008.0754. [PMID] 18613791.
2008
The orphan G protein-coupled receptor 161 is required for left-right patterning.
Developmental biology. 323(1):31-40 [DOI] 10.1016/j.ydbio.2008.08.001. [PMID] 18755178.
2007
Expression of the G protein gammaT1 subunit during zebrafish development.
Gene expression patterns : GEP. 7(5):574-83 [PMID] 17306630.
2006
Runx-dependent regulation of G-protein gamma3 expression in T-cells.
Cellular immunology. 240(2):86-95 [PMID] 16904090.
2006
Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.
Blood. 108(1):160-6 [PMID] 16537812.
2004
Mice with deficiency of G protein gamma3 are lean and have seizures.
Molecular and cellular biology. 24(17):7758-68 [PMID] 15314181.
2004
Ribozymes as tools for suppression of G protein gamma subunits.
Methods in molecular biology (Clifton, N.J.). 237:169-80 [PMID] 14501049.
2004
Translating G protein subunit diversity into functional specificity.
Current opinion in cell biology. 16(2):206-9 [PMID] 15196565.
2003
Functional genomic dissection of multimeric protein families in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):555-67 [PMID] 14579392.
2003
Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production.
The Journal of biological chemistry. 278(8):6575-9 [PMID] 12488442.
2002
Ribozyme-mediated suppression of G protein gamma subunits.
Methods in enzymology. 344:435-51 [PMID] 11771402.
2001
Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase.
The Journal of biological chemistry. 276(42):39386-93 [PMID] 11500503.
2001
Heterotrimeric G-protein betagamma-dimers in growth and differentiation.
Oncogene. 20(13):1653-60 [PMID] 11313913.
2000
A major locus for myoclonus-dystonia maps to chromosome 7q in eight families.
American journal of human genetics. 67(5):1314-9 [PMID] 11022010.
2000
Alpha-1 adrenergic signaling in a cardiac murine atrial myocyte (HL-1) cell line.
Molecular and cellular biochemistry. 214(1-2):111-9 [PMID] 11195782.
2000
Constitutively active mutants of the alpha(1a)- and the alpha(1b)-adrenergic receptor subtypes reveal coupling to different signaling pathways and physiological responses in rat cardiac myocytes.
The Journal of biological chemistry. 275(3):2087-97 [PMID] 10636913.
2000
Human G protein gamma(11) and gamma(14) subtypes define a new functional subclass.
Experimental cell research. 257(2):310-9 [PMID] 10837145.
1999
Ribozyme approach identifies a functional association between the G protein beta1gamma7 subunits in the beta-adrenergic receptor signaling pathway.
The Journal of biological chemistry. 274(24):17365-71 [PMID] 10358098.
1999
The alpha2A-adrenergic receptor discriminates between Gi heterotrimers of different betagamma subunit composition in Sf9 insect cell membranes.
The Journal of biological chemistry. 274(19):13525-33 [PMID] 10224121.
1998
Muscarinic K+ channel in the heart. Modal regulation by G protein beta gamma subunits.
The Journal of general physiology. 112(2):199-210 [PMID] 9689027.
1997
Differential coupling of alpha1-adrenoreceptor subtypes to phospholipase C and mitogen activated protein kinase in neonatal rat cardiac myocytes.
European journal of pharmacology. 339(1):77-86 [PMID] 9450619.
1997
G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 1. Reduced membrane-associated G-protein content due to diminished isoprenylation of G-gamma subunits and p21ras.
Biochemistry. 36(31):9523-31 [PMID] 9235998.
1997
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America. 94(6):2180-5 [PMID] 9122168.
1997
Ribozyme-mediated suppression of the G protein gamma7 subunit suggests a role in hormone regulation of adenylylcyclase activity.
The Journal of biological chemistry. 272(41):26040-8 [PMID] 9325341.
1996
G-protein alpha subunit Gi(alpha)2 mediates erythropoietin signal transduction in human erythroid precursors.
The Journal of clinical investigation. 98(8):1728-36 [PMID] 8878422.
1996
Gβγ-Mediated signaling in the heart: Implications of β and γ subunit heterogeneity.
Trends in cardiovascular medicine. 6(4):115-21 [DOI] 10.1016/1050-1738(96)00021-7. [PMID] 21232284.
1995
Bovine brain GO isoforms have distinct gamma subunit compositions.
The Journal of biological chemistry. 270(9):4189-92 [PMID] 7876173.
1995
Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.
The Journal of biological chemistry. 270(37):21765-71 [PMID] 7665596.
1995
Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells. Possible role of G gamma 2.
The Journal of biological chemistry. 270(11):5901-8 [PMID] 7890721.
1995
Regions outside of the CAAX motif influence the specificity of prenylation of G protein gamma subunits.
The Journal of biological chemistry. 270(24):14835-41 [PMID] 7782351.
1995
Specificity of G protein alpha-gamma subunit interactions. N-terminal 15 amino acids of gamma subunit specifies interaction with alpha subunit.
The Journal of biological chemistry. 270(7):2946-51 [PMID] 7852373.
1995
Subunit expression of signal transducing G proteins in cardiac tissue: implications for phospholipase C-beta regulation.
Journal of molecular and cellular cardiology. 27(1):471-84 [PMID] 7760367.
1994
Cloning and sequencing of a rat heart cDNA encoding a G-protein beta subunit related to the human retinal beta 3 subunit.
Gene. 149(2):337-40 [PMID] 7959013.
1994
Direct interaction of the alpha and gamma subunits of the G proteins. Purification and analysis by limited proteolysis.
The Journal of biological chemistry. 269(5):3574-80 [PMID] 8106401.
1994
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
The Journal of biological chemistry. 269(6):4388-95 [PMID] 8308009.
1994
Ins 1,4,5-P3 and Ca2+ signaling in quiescent neonatal cardiac myocytes.
Biochimica et biophysica acta. 1224(3):517-26 [PMID] 7803511.
1994
Localization of a heterotrimeric G protein gamma subunit to focal adhesions and associated stress fibers.
The Journal of cell biology. 126(3):811-9 [PMID] 8045942.
1994
Preparation, characterization, and use of antibodies with specificity for G-protein gamma subunits.
Methods in enzymology. 237:498-509 [PMID] 7935023.
1994
Role of carboxylmethylation in chemoattractant receptor-stimulated G protein activation and functional responses.
Biochemical and biophysical research communications. 200(3):1604-14 [PMID] 8185616.
1994
Structure and function of G proteins mediating signal transduction pathways in the heart.
Alcoholism, clinical and experimental research. 18(1):115-20 [PMID] 8198206.
1993
A high temperature transfer procedure for detection of G protein gamma subunits by immunoblotting.
Analytical biochemistry. 208(2):283-7 [PMID] 7680843.
1992
Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system.
The Journal of biological chemistry. 267(19):13123-6 [PMID] 1618813.
1992
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma.
The Journal of biological chemistry. 267(32):23409-17 [PMID] 1429682.
1992
Production, processing and partial purification of functional G protein beta gamma subunits in baculovirus-infected insect cells.
The Biochemical journal. 286 ( Pt 3)(Pt 3):677-80 [PMID] 1417725.
1992
Retinal rods and cones have distinct G protein beta and gamma subunits.
Proceedings of the National Academy of Sciences of the United States of America. 89(22):10882-6 [PMID] 1438293.
1992
Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.
The Journal of biological chemistry. 267(33):24023-7 [PMID] 1385432.
1991
Effect of calcium and cAMP on Go alpha expression in neonatal rat cardiac myocytes.
The American journal of physiology. 261(4 Suppl):15-20 [DOI] 10.1152/ajpheart.1991.261.4.15. [PMID] 1656793.
1991
Role of pertussis toxin-sensitive guanosine triphosphate-binding proteins in the response of erythroblasts to erythropoietin.
Blood. 77(3):486-92 [PMID] 1899345.
1991
The effect of culture and membrane potential on Go alpha expression in neonatal rat cardiac myocytes.
Molecular and cellular biochemistry. 104(1-2):63-72 [PMID] 1922003.
1990
Expression of G proteins in rat cardiac myocytes: effect of KCl depolarization.
The American journal of physiology. 259(2 Pt 2):H432-41 [PMID] 2117401.
1990
Influence of thyroid hormone status on expression of genes encoding G protein subunits in the rat heart.
The Journal of biological chemistry. 265(6):3553-60 [PMID] 1689305.
1990
Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.
The Journal of biological chemistry. 265(30):18071-4 [PMID] 2120222.
1989
Existence of two gamma subunits of the G proteins in brain.
The Journal of biological chemistry. 264(27):15758-61 [PMID] 2506169.
1989
Metabolism of pantothenic acid in hearts of diabetic rats.
Journal of molecular and cellular cardiology. 21(7):641-9 [PMID] 2795660.
1989
Role of G proteins in the regulation of the cardiovascular system.
Annual review of physiology. 51:229-44 [PMID] 2565700.
1987
A second form of the beta subunit of signal-transducing G proteins.
Proceedings of the National Academy of Sciences of the United States of America. 84(17):6122-5 [PMID] 3114742.
1986
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America. 83(5):1251-5 [PMID] 3081893.
1986
Molecular basis for two forms of the G protein that stimulates adenylate cyclase.
The Journal of biological chemistry. 261(21):9587-90 [PMID] 3015900.
1985
Coenzyme A metabolism.
The American journal of physiology. 248(1 Pt 1):E1-9 [PMID] 2981478.
1985
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase.
Science (New York, N.Y.). 229(4719):1274-7 [PMID] 3839937.
1985
The properties and regulation of pantothenate kinase from rat heart.
The Journal of biological chemistry. 260(29):15745-51 [PMID] 2999132.
1984
Differential effects of cysteine on protein and coenzyme A synthesis in rat heart.
The American journal of physiology. 247(1 Pt 1):C99-106 [PMID] 6204541.
1984
Homologies between signal transducing G proteins and ras gene products.
Science (New York, N.Y.). 226(4676):860-2 [PMID] 6436980.
1984
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
The Journal of biological chemistry. 259(22):13806-13 [PMID] 6438083.
1984
Pantothenate kinase and control of CoA synthesis in heart.
The American journal of physiology. 246(4 Pt 2):H532-41 [PMID] 6326596.
1982
Control of myocardial levels of CoA and carnitine.
Journal of molecular and cellular cardiology. 14 Suppl 3:37-42 [PMID] 6754954.
1982
Rate-limiting step and control of coenzyme A synthesis in cardiac muscle.
The Journal of biological chemistry. 257(18):10967-72 [PMID] 7107640.
1981
Protection of ischemic myocardium from metabolic products.
Acta medica Scandinavica. Supplementum. 651:13-8 [PMID] 6948500.

Grants

Jul 2024 ACTIVE
The involvement of GPR37L1 on a chronic migraine-like state
Role: Principal Investigator
Funding: FL ATLANTIC UNIV via NATL INST OF HLTH NINDS
Aug 2023 ACTIVE
New Frontiers in the prevention of Dementia
Role: Principal Investigator
Funding: FL ATLANTIC UNIV via HARRY T MANGURIAN JR FOU
Aug 2023 – Sep 2024
Developing a precise, localized, community focused, population health framework in an FQHC to tackle chronic disease disparities through EHR data
Role: Principal Investigator
Funding: FL ATLANTIC UNIV via NATL INST OF HLTH
Jul 2023 ACTIVE
Developing a P4 Medicine Approach to Obstructive Sleep Apnea
Role: Principal Investigator
Funding: UNIV OF PENNSYLVANIA via NATL INST OF HLTH NHLBI

Contact Details

Phones:
Business:
(352) 273-8859
Emails:
Business:
robishawj@ufl.edu
Addresses:
Business Street:
2015 SW 16TH AVE
GAINESVILLE FL 32608

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