Controlled non-inferiority trial evaluating the use of liposomal bupivacaine on postoperative analgesia in canine hindlimb amputations

The University of Florida Small Animal Hospital is recruiting dogs for a clinical study:

Enrollment Status: Currently Enrolling

Inclusion Criteria: Dogs undergoing a hindlimb amputation as part of their clinical care.

Procedures: Before being placed under general anesthesia, dogs will receive an injection of a pain medication to block the nerves (local anesthetic) going to the hindlimb being amputated. The dogs will randomly be divided into two groups: one group will receive the study treatment (liposomal bupivacaine), and the other group will receive the current standard of care treatment (regular bupivacaine).

All dogs will receive an anti-inflammatory medication at the end of surgery and every 12 hours after surgery. After surgery, dogs will be carefully monitored for any signs of pain. Blood samples will be taken at regular time intervals to measure cortisol levels, which is an indication of stress. Dogs will remain in the hospital for at least 24 hours if no complications are encountered.

Cost: The study will cover the cost of stress hormone (cortisol) testing, liposomal bupivacaine solution if randomly assigned to this treatment group, and hospitalization for one night post operatively.

Principal Investigator(s): Dr. Diego Portela and Dr. Elizabeth Maxwell

Background: Our goal is to determine if using a novel long-acting local anesthetic drug (liposomal bupivacaine solution) to numb the nerves in the hindleg during hind limb amputation would be comparable with the standard pain medications used for postoperative pain relief in dogs undergoing this type of surgery. We will also evaluate the postoperative stress response by measuring the stress hormone cortisol among dogs receiving the study treatment versus the standard of care treatment.


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