Evaluation of Staphylococcus Felis Protein Extract as a Probiotic Treatment for Canine Pyoderma

The University of Florida College of Veterinary Medicine is currently recruiting dogs diagnosed with canine superficial pyoderma

Enrollment Status: Enrollment On Hold

Inclusion criteria: Dogs diagnosed with canine superficial pyoderma being seen by University of Florida Veterinary Hospital clinicians or referral clinicians are eligible to be enrolled. To participate, the dog must be over one year of age and not have received any topical medication on the skin for the last seven days or received a bath or any other topical hygiene product for the last two weeks. There is no restriction related to breed, weight, or sex.

Exclusion criteria: Dogs currently receiving topical or systemic antibiotics.

Treatment:  Dogs with superficial pyoderma will be minimally manually restrained during these procedures. Swabs will be collected from the skin on areas that have lesions and the surrounding normal skin. Dogs will receive topical application of either S. felis protein extract, or a topical application with no active ingredients (placebo). Then, the dogs will receive additional applications for 7 days, twice a day, daily. The owner will be responsible for applying the products, and written instructions and personal protective equipment will be provided. Re-evaluations will be performed at 7 days, 14 days, and 28 days after the beginning of the treatment.

Cost: The study will pay for each visit, the dermatology exam, the cytology, the probiotic drug, and provide personal protective equipment to owners to apply the drug. No other costs will be covered. The owners might be responsible for costs associated with assessment, diagnosis, and/or treatment of the participating animal.

Contacts: You can contact our Small Animal Hospital at (352) 392-2235, or complete the Study Interest Form to see if your dog qualifies.

Background: Canine superficial pyoderma is one of the most common skin diseases in dogs. It can be especially problematic in animals that have other underlying skin conditions, such as atopic dermatitis, when superficial pyoderma tends to frequently recur. Because of that, prolonged and repeated use of antibiotics may be required, which can increase the risk of development of multidrug resistant bacteria. Our goal is to evaluate the efficacy of a new probiotic drug derived from Staphylococcus felis, a commensal bacteria found in cats, in the treatment of canine pyoderma, reducing the need for antibiotic therapy.


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