This study is currently CLOSED. Inclusion criteria: Client-owned dogs of any breed or sex weighing 15-60kg (33-132 lbs.), presenting with naturally occurring OA of the carpus, elbow, shoulder, tarsus, stifle, and/or hip joint(s) will be eligible for enrollment. Dogs will be included if they have clinical signs attributable to OA, as well as radiographic evidence of … Continue reading Evaluation of the effect of mitragynine on naturally occurring osteoarthritic pain in a canine model, a prospective, randomized, crossover, double-blinded, placebo-controlled clinical trial