Percutaneous cementoplasty in dogs with appendicular osteosarcoma treated with stereotactic body radiation therapy: Evaluation of safety and efficacy in reducing pain and risk of pathological fracture

The University of Florida College of Veterinary Medicine is currently recruiting dogs diagnosed with osteosarcoma (OSA) for a clinical research trial. This trial will be investigating the effects of percutaneous cementoplasty (PC) in patients undergoing radiation therapy.

Enrollment Status: Currently Enrolling

Inclusion Criteria: Any dog diagnosed with appendicular osteosarcoma that will be undergoing radiation therapy. The doctors will explain this to you.

Treatment: Your dog is being offered enrollment in this study because he/she has OSA. As part of the study, dogs treated with stereotactic body radiation therapy (SBRT), will undergo PC 2 weeks later (+/- 1 week). Right after PC, both radiographs and CT scan of the limb will be taken. Scheduled follow-up rechecks will occur at 2 weeks, and 5 weeks (+/-1) post-PC, then every 3 months until disease progression. The degree of lameness will be evaluated by us through an objective gait analysis and lameness score system before each treatment, and at scheduled rechecks. We will also ask you that a short pain/lameness assessment be filled out at the same time points. We will see your dog for an unscheduled visit if any problems arise.

Cost: The study will cover the cost of the PC surgery, CT scan and radiographs of the limb post-PC, as well as the gait analysis at rechecks. · Contact: Contact the Oncology Staff at (352) 392-2235 to schedule an evaluation, or complete the Study Interest Form to see if your dog qualifies.

Background: Osteosarcoma is a type of cancer that can damage the bone, making it more fragile and susceptible to fracture. Percutaneous cementoplasty (PC) is a minimally invasive technique that injects cement into the damaged bone. Dogs are treated with radiation therapy to treat pain and achieve local tumor control. However, dogs treated with stereotactic radiation therapy may be at a higher risk for bone fracture. The goal of this research project is to evaluate if PC, after treatment with radiation, helps reduce pain and decrease the risks of pathological fracture in dogs with osteosarcoma, so they can have a prolonged, pain-free limb function.